Efficacy of Dawa-ul-Khasak in treatment of erectile Dysfunction: An exploratory, single arm pre and post clinical trial

Abstract

Background and Objectives:Erectile Dysfunction or Impotence is defined as inability to achieve or maintain an erection sufficient for satisfactory sexual performance. ED is well-defined under the heading of Zoaf-e-bah with the synonyms such as Nuqs-e-Nauoz, Zoaf-e-Inaaz, Isterqa-e-Qazeeb. Methods: 30 eligible patients of Erectile Dysfunction with IIEF-15 Score < 24were enrolled in an open, single arm, pre and post, exploratory clinical trial with 4 weeks treatment duration. The test drug Dawa-ul-Khasak, with a dose of 7gms twice a day given. The effect of the study was assessed subjective and objectively in different follow ups. Patients were assessed for improvement in erectile function and sexual quality of life by using IIEF-15 Score and SQoL-M Scales respectively every 14thand 28thday of treatment. Patients were also assessed for subjective parameter on 7th, 14th, 21st and 28th day of study. Results: The Mean ± SD of variable Erectile Function (EF), Orgasmic Function (OF), Sexual Desire (SD), Intercourse Satisfaction (IS) and Overall Satisfaction (OS) at 0 daywere 14.43±3.65, 5.57±2.13, 5.43±1.33, 6.90±1.99 and 4.50±1.25 respectively; while it was increases to 23.37±3.47, 7.67±1.65, 6.97±1.56, 10.33±2.56 and 7.27±1.05 respectively;at 28th day of the study with highly significant ‘p’ value of