Effect of Origanum vulgare on perennial allergic rhinitis: A pilot randomized placebo-controlled clinical trial

Abstract

Oregano is a medicinal plant; this study was conducted to evaluate the efficacy of nasal oregano spray in patients with allergic rhinitis. This study was a randomized double-blind placebo controlled trial on forty patients with perennial allergic rhinitis who were randomly allocated to receive either nasal oregano or placebo spray twice a day for6 weeks continuously. Evaluation of the participant’s allergy score was performed before and after the intervention using the Rhinitis Quality of Life Questionnaire (RQLQ). Twenty-eight patients with allergicrhinit is completed the experiment (active 12, placebo 16) till the end of the 6thweek. With the adjustment of the allergy score at baseline, the symptoms of allergic rhinitis was significantly improved in the intervention group compared to the controls (regression coefficient= -2.5±1.11; P-value=0.03). This study suggests that nasal oregano spray could be an effective complementary treatment in patients suffering allergic rhinitis.