Comparative evaluation of haemato biochemical changes after intravenous administration of dexmedetomidine-butorphanol and dexmedetomidine-midazolam as preanaesthetic with propofol anaesthesia in dog

Abstract

A combination of drugs may be preferred over the use of a single agent to induce deep sedation and the synergistic interaction between the drugs reduces the dose requirements of the drugs thereby minimising the unwanted side effects associated with each drug and improving recovery with this aim the present study was conducted to compare and evaluate the intravenous dexmedetomidine-butorphanol and dexmedetomidine-midazolam as preanaesthetic with propofol anaesthesia in dog. The study was conducted on 14 (fourteen) clinical cases of dogs of either sex, irrespective of age presented to the T.V.C.C., COVAS, Parbhani for various surgical interventions randomly divided into two groups each consisting of seven dogs. All the dogs in study were administered with inj. Atropine sulphate @ 0.04 mg/kg body weight subcutaneously. In group A, after administration of inj. Atropine sulphate, 10 min later combination of Inj. Dexmedetomidine HCL (10 µg/kg body weight) and Inj. But orphanol tartarate (0.2 mg/kg body weight) mixed in single syringe was administered intravenously whereas in group B, combination of Inj. Dexmedetomidine HCL (10 µg/kg body weight) and Inj. Midazolam maleate (0.2 mg/kg body weight) mixed in single syringe was administered intravenously. Quality of sedation was assessed followed by inj. Propofol was administered till the effect to get the surgical stage of anaesthesia and required amount was calculated as induction dose. Intermittent doses of propofol were given for maintenance of anaesthesia when required. Overall significant difference haemoglobin (P