Thyrogenic, hypolipidemic and antioxidant effects of Bacopa monnieri (Brahmi) on experimental hypothyroidism in rats

Abstract

Bacopa monnieri commonly known as Brahmi is one of the commonly available and well known herbs in India. It has been used as a brain tonic and recommended for treating poor cognition and lack of concentration in humans. The present study was undertaken to assess the effects of Brahmi on experimentally induced hypothyroidism in male Wistar rats, which is less known. Hypothyroid rats were treated with 200 mg per kg of Brahmi and levothyroxine has been used as a standard replacement drug. Plasma levels of thyroid hormones (T3, T4 & TSH), lipid profile and liver anti-oxidants (catalase, superoxide dismutase, reduced glutathione and lipid peroxidation levels) were determined. Histological study of the thyroid glands was carried out. The results thus obtained suggest that Brahmi ameliorated hypothyroidism as evidenced by reversal of various biochemical changes as well histology of thyroid gland in rats. Thus the plant could be considered for therapeutic management of clinical conditions associated with hypothyroidism.