A prospective comparative study of intranasal dexmedetomidine and clonidine on sedation and hemodynamic response during laryngoscopy in adult patients

Abstract

In general anesthesia, hemodynamic changes during endotracheal intubation are major concerns. Sedative premedications like Dexmedetomidine and Clonidine, when used intranasally are effective options for reduction of preoperative anxiety and preventing untoward hemodynamic responses at the time of induction. Thirty eight patients of ASA 1 and 2 aged 18-70 years were randomly allocated in 2 groups of 19 patients: Group C received inj. Clonidine 3 mcg/kg and Group D received inj. Dexmedetomidine 1 mcg/kg intranasally 45 min before induction. All patients were monitored after premeditation and throughout the surgery. We observed sedation, HR, SBP, DBP, MAP and SPO2 at various intervals. Intranasal Dexmedetomidine was found to be more effective in producing perioperative sedation and more stable hemodynamics at the time of induction. Dexmedetomidine via intranasal route can be considered as a useful alternative of conventional medications to produce sedation and to blunt hemodynamic response during laryngoscopy.