Role of platelet rich plasma in chronic non- healing ulcer: An observational study

Abstract

Diabetic foot ulcer is a major complication of diabetes mellitus. Patients with poorly controlled diabetes, can develop ulcer around their feet for which amputation is the last resort and risk of re-amputation is high. Over the recent years, great progress has been made in the techniques of wound healing, among which autologous platelet-rich plasma (PRP) has attracted the most substantial attention. This was a prospectively designed study that evaluated the effect of PRP in patients with different types of ulcers. 70 patients with 82 non healing ulcers of various etiologies were treated with PRP at weekly intervals. The mean age of the patients was 42.5 years. the mean duration of ulcers was 4.75 months. About 100% improvement in the area was seen in 25 of the ulcers and 100% improvement in volume was seen in 24 of the ulcers at the end of the treatment. There was reduction in pain and discharge within 1 week. There were no side effects noted.