Effect of bleomycin (BLM) induced toxicity on body weights and hematological parameters and protective role of whole pomegranate juice in rats

Abstract

The ameliorative potential of whole Pomegranate fruit juice was studied against Bleomycin (BLM) induced toxicity on body weights (b.wts) and hematological parameters in rats. A total of 48 male albino Wistar rats were procured and divided into 4 groups consisting of 12 rats in each. The group 1 - control, group 2 - BLM {@ 5 mg/kg b.wt via single intra-tracheal (IT) instillation}, group 3 - BLM (@ 5 mg/kg b.wt via single IT instillation) + Pomegranate juice (@ 1 mL/rat once daily orally) and group 4 - Pomegranate juice (@ 1 mL/rat once daily orally). The experiment was carried out for a period of 28 days and six rats from each group were sacrificed on 14th and 28th day of the experiment. Significantly (P