Comparative study of pregnancy- related complications of women with and without polycystic ovary syndrome (PCOS)

Abstract

Background: Polycystic ovarian syndrome (PCOS) is a multifactorial metabolic condition, characterised by infertility, anovulation, hyperandrogenism and increased risk for many metabolic diseases like Diabetes mellitus. Materials & Methods: A prospective cohort study of 100 pregnant women (50 women with PCOS and 50 women without PCOS) aged 20-35 years attending the gynaecology outpatient department of VMKV Medical college and hospital was conducted from over a period of 18 months to determine the maternal complications associated with PCOS.Results: Mean age of the participants is 26.5. The participants with overweight/obesity are 34.0% among the women with PCOS when compared to 26.0% among the women without PCOS (p=0.375). Gestational diabetes is reported in 23.4% women with PCOS as against 14.6% women without PCOS. Women with PCOS are having 2.65 times the higher risk of having pre-eclampsia. Primigravida are having 2.89 times higher chance of presenting with PCOS.Conclusion: Among the women with PCOS, GDM and pre-eclampsia are the common pregnancy related complications. Obesity is independently associated with GDM, pre-eclampsia and spontaneous abortion.