Fragmentation in embryos: Still an enigma

Abstract

Fragmentation is commonly seen in human embryos developing in-vitro. Based on severity of fragmentation, development potential of the embryos is estimated. But the proportion of the fragmentation at which developmental potential of the embryos starts to decrease is not known. Recent studies indicate that fragmentation affects developmental potential of the embryos if specific genes are involved in the fragment formation. Thus, considering only percentage of fragmentation can lead to erroneous judgment regarding developmental potential of the embryos. Fragmentation is also considered as parameter of apoptosis happening in the embryos. But this association is also being refuted in newer research. Moreover, time at which fragmentation develops and stage of the embryo at which fragmentation develops and its effect on development of the embryos has not been studied extensively. Thus, extensive research is required to get clear picture of fragmentation and its effect on the developmental potential of the embryos.