Evaluation of serum vascular endothelial growth factor (Vegf) and microalbuminuria in early diabetic nephropathy

Abstract

Aim: To evaluate serum vascular endothelial growth factor (VEGF) and urinary microalbumin for early detection of diabetic nephropathy. Method: The diabetic patients visiting the Medicine OPD were selected and evaluated for serum vascular endothelial growth factor and urinary microalbumin. The patients were divided into groups according to duration of diabetes. Group 1 with diabetes between 5-10 years, Group 2 with diabetes between 10-15 years, Group 3 with diabetes more than 15 years and Control Group. Results: Serum VEGF level along with urinary microalbumin increased significantly in Group 2 (10-15 years duration) and further increases with increasing diabetic duration. Conclusion: Serum vascular endothelial growth factor (VEGF) along with appearance of microalbumin in urine can predict diabetic nephropathy in early stages.