Assessment of the serum levels of nitric oxide among diabetic patients and its correlation with lipid profile as well as oxidative stress

Abstract

Background and Aim: Endothelial dysfunction appears to be a consistent finding in all diabetic patients. Indeed, there is a general agreement that chronic hyperglycemia and DM lead to impairment in nitric oxide (NO) production and activity. The present study was conducted to assess the serum levels of NitricOxide (NO) among diabetic patients and its correlation with lipid profile as well as oxidative stress.Material and Methods: The present study was conducted among 99 patients of diabetes of both genders. The patients were divided into three groups: Group I were type 2 diabetics with dyslipidemia and hyperuricaemia, group II was type 2 diabetics with dyslipidemia and normouricaemia and group III was type 2 diabetics with normolipidemic and normouricaemia. Lipid profile and nitric oxide were determined.Results: There was a non-significant difference in HbA1c, TC, TG, HDL and LDL among different differences (P> 0.05). There was poor correlation of antioxidants with NO levels (P> 0.05)Conclusion: There was a role of Nitric Oxide (NO) in the pathogenesis of type -2 diabetes mellitus with dyslipidemia and hyperuricaemia. The oxidative stress parameters had poor correlation with NO level in all the groups.