A study on correlates of chronic kidney disease

Abstract

CKD is associated with increased activity of the RAAS. There is reduced blood flow in peritubular capillaries downstream of sclerosed glomeruli. As a result of this reduced effective (perceived) blood flow, glomeruli in these regions hyper secrete renin, thereby increasing circulating angiotensin II levels. Angiotensin II has a direct vasoconstrictor effect, which increases systemic vascular resistance and BP. A pre-structured proforma was prepared be used to collect demographic data which included age, gender, occupation history of present illness, Past history, family history and personal history including history of smoking, alcohol. Pearsons correlation (two tailed with 95% CI) for CKD stage and hemoglobin levels shows significant negative correlation with r value of -0.6176analysis shows with a P value of