Association of serum calcium, phosphrous and parathyroid hormone with cardiac abnormality in CKD patients: A pilot study

Abstract

Chronic kidney disease is commonly associated with increase in blood phosphate levels. In early stages phosphate levels are maintained in normal limits because of the hyperparathyroidism causing phosphaturia. With advancement in renal disease hyperphosphatemia becomes evident. As a consequence of same there will be worsening of hyperparathyroidism and predisposition to develop metastatic calcification. In this study we have analyzed the serum levels of Calcium, Phosphorous and Parathormone levels in chronic kidney disease patients who were evaluated in nephrourology centre over a period of one month. It was then evaluated to see the correlation between aforementioned parameters with cardiovascular disease in those patients. The study showed significant correlation between the serum phosphate levels with cardiovascular morbidity in study population but didn’t show significant relation with serum calcium and parathormone levels. From the study it can be concluded that a large percentage of end stage renal disease patients have high phosphate levels and this plays a significant role in cardiovascular morbidity in them.