Serum CPK levels as prognostic marker in development of intermediate syndrome in acute op poisoning

Abstract

Organophosphorous (OP) compound poisoning is one of the common cases presenting to medical emergency. Erythrocyte cholinesterase (EchE) and pseudocholinesterase (Butyryl cholinesterase – BchE) are markers used for assessing the severity in OP poisoning. However due to the high expense of this marker there is requirement of better and less expensive marker like Creatinine phosphokinase (CPK). Our study was conducted among hundred patients who presented to the hospital over a period of one year. Thorough clinical examination of patients was done at admission along with laboratory values of serum CPK level assessment. Patients were monitored during hospital stay. Out of study population majority were male and in age group of 21-40 years. Thirty four patients had elevated CPK levels at admission which correlated with development of intermediate syndrome. Thus due to ease of availability and being less expensive CPK levels can be used as prognostic marker in op poisoning.