Antiplasmodial, inhibitor of hemozoin synthesis and antioxidant activities of some plants used as antimalarial drugs in Bagira (DR Congo)

Abstract

This study was carried out to evaluate antiplasmodial, inhibitor of hemozoin synthesis and antioxidant activities of 10 plants used in traditional medicine in Bagira in the treatment of malaria. Antiplasmodial activity was carried out by pLDH assay and inhibitory activity of the synthesis of hemozoin, by b-hematin formation assay. The antioxidant activity was evaluated by the DPPH assay. Six plants showed a good activity on W2 strain among them 3 plants showed an inhibitory activity on synthesis of hemozoin and all an antioxidant activity. Dialium angolense, Dalbergia katangensis and Ochna schweinfurthiana showed all tree interest activities with IC50≤ 14.7 ± 0.7 µg / mL. This result establishes a scientific basis for the use of these plants in traditional medicine and highlights a mechanism of action of 3 of them. It prompts the continuation of preferential work to isolate the actives compounds or to develop an improved traditional medicine