Changes in haemato-biochemical and urine indices in response to the intravenous administration of amikacin

Abstract

Amikacin is the most commonly used aminoglycoside to treat a variety of serious infections caused by aerobic gram-negative bacteria, as well as mycobacteria and Nocardia in animals. Due to its inherent property of being refractory to most of the aminoglycoside modifying enzymes. These antibiotics is their relatively low therapeutic index. The use at therapeutic dosage may lead to adverse changes in haemato-biochemical indices, especially with those connected with kidney and liver function. The aim of the present study was to determine the changes in some and haemato-biochemical parameters during 5 days intravascular administration with amikacin (10 mg/kg bwt) in four healthy non lactating female goats. The results of these studies indicated that in healthy goats, at the therapeutic dosage, caused significant (p