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Coronavirus disease 2019 vaccine response in pregnant and lactating women: a cohort study

American Journal of Obstetrics and Gynecology · 2021 · Vol. 225(3) · pp. 303.e1–303.e17

Kathryn J. Gray(Brigham and Women's Hospital)Evan A. Bordt(Harvard University)Caroline Atyeo(Harvard University)Elizabeth A. DeRiso(Ragon Institute of MGH, MIT and Harvard)Babatunde Akinwunmi(Brigham and Women's Hospital)Nicola Young(Harvard University)Aranxta Medina Baez(Harvard University)Lydia L. Shook(Harvard University)Dana Cvrk(Harvard University)Kaitlyn James(Harvard University)Rose M. De Guzman(Harvard University)Sara Brigida(Harvard University)Khady Diouf(Brigham and Women's Hospital)Ilona T. Goldfarb(Harvard University)Lisa M. Bebell(Harvard University)Lael M. Yonker(Harvard University)Alessio Fasano(Harvard University)S. Alireza Rabi(Harvard University)Michal A. Elovitz(University of Pennsylvania)Galit Alter✉(Ragon Institute of MGH, MIT and Harvard)Andrea G. Edlow✉(Harvard University)

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Abstract

Coronavirus disease 2019 messenger RNA vaccines generated robust humoral immunity in pregnant and lactating women, with immunogenicity and reactogenicity similar to that observed in nonpregnant women. Vaccine-induced immune responses were statistically significantly greater than the response to natural infection. Immune transfer to neonates occurred via placenta and breastmilk.

COVID-19 Impact on Reproduction Pregnancy and Medication Impact Reproductive System and PregnancyMedicineCohortPregnancyCoronavirus disease 2019 (COVID-19)CoronavirusCohort studyDiseaseObstetricsSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)2019-20 coronavirus outbreak

Funding

Bill and Melinda Gates Foundation
Brigham and Women's Hospital
Massachusetts General Hospital
Massachusetts Institute of Technology
University of Pennsylvania
Harvard University
Musk Foundation
Massachusetts Consortium on Pathogen Readiness
National Institutes of Health
Perelman School of Medicine, University of Pennsylvania
National Heart, Lung, and Blood Institute
National Institute of Allergy and Infectious Diseases
National Institute of Child Health and Human Development
Eunice Kennedy Shriver National Institute of Child Health and Human Development

Citations

670

FWCI

98.54

field-weighted impact

References

Percentile

100%

vs. same field & year

Citations per year

References

Coronavirus disease 2019 (COVID-19) pandemic and pregnancy

American Journal of Obstetrics and Gynecology · 2020 · 1,457 citations

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