A review on type of interaction of DNA with DNA binding agents

Abstract

The study of selective interactions of drugs, proteins and small molecules with DNA is very exciting and significant not only in understanding the mechanism of interaction, but also for the design of new drugs. Understanding how drug molecules interact with DNA has become an active research area at the interface between chemistry, molecular biology and medicine. The interaction of protein with DNA plays a crucial role in the function of regulatory proteins. In this review article, we attempt to bring together topics that cover the breadth of this large area of research via explaining the covalent and non-covalent binding.