Elevated circulating level of xenopsin related 1-are associated with PCOS (Polycystic Ovarian Syndrome)

Abstract

Background: Polycystic ovary syndrome is a common metabolic and endocrine disorder affecting 6 to 21% of reproductive aged women depending on population, mean body mass index and diagnostic criteria used. High prevalence is rates seen in women whom are overweight or have an Indigenous or Asian background. Xenin is a peptide hormone produced by a subpopulation of chromogranin A-positive endocrine cells in the mucous membrane of the duodenum. In humans, xenin circulates in the blood plasma.Aim of the study: To determine the role of xenopsin level in polycystic ovarian syndrome.Patients and methods: Observational case control study, conducted in Salah Aldin general hospital in Obstetrics and gynecological department, from (the first of Fab 2018 to the end of Dec. 2018). 40 patients with PCOS and 40 healthy women were included in the study.Results: the mean age of PCOS group was 29±2.30 years and 28±7.20 years for control group. Sensitivity of the test to diagnose the PCOS were (88.0%), the specificity (89.0%), positive predictive value (86.0%), negative predictive value (84.0%) and the accuracy of the test to diagnose the PCOS was (88.6%).Conclusion: Highly significant increase in Xenopsin level in PCOS group than that in control group.