Assessment of serum vitamin D levels in patients with vitiligo

Abstract

Background: Vitiligo is an autoimmune pigment disease, and is marked by well-defined depigmented patches or macules attributable to the loss of functioning melanocytes in the epidermis and hair infundibulum. Objective: To test serum levels of Vitamin D and contrast effects and controls in vitligo patients.Methods: It is a case-control study conducted in a hospital setting that involves 100 patients out of which 50 cases and 50 controls. All of those participating in the study underwent a thorough general physical examination. A comprehensive systematic analysis for related diseases has also been carried out and the outcomes have been noted. In order to identify the condition and to know the nature of the vitiligo and to examine particular characteristics, such as trichrome, quadrichrome and leukotrichia, a thorough dermal analysis including mucosa has been conducted.Results: The majority of the patients belonged to the age group of 21 to 40 years around 37%. The majority of our study subjects were male constituting 53% and females were 47%. The most prominent vitiligo seen was Vulgaris in 48%. In 72% of the cases, the duration of Vitiligo was < 5 yrs. 54% of the patients in the Case group and 52% of the patients in the control group had Serum Vitamin D deficiency. In 26% of the patients in the Case group and 8% in the control group had severe Vitamin D deficiency.Conclusion: The serum cholecalciferol and vitiligo are strongly associated with this analysis. The clinical type, duration, and severity of vitiligo are also greatly associated with cholecalciferol.