Cytotoxic activity of leaves extract of pomegranate (Punica granatum L.)

Abstract

Cancer is a pathological condition where excessive and abnormal cell growth leads to widespread invasion within the body to affect various organ functions. It is known that chemotherapeutic agents are themselves possible candidates of cancer generation as they can kill normal cells. Nowadays, there is an immense interest for the search herbal formulation with cancer-preventive effect because of the problems, generated with existing chemotherapeutic regimens. Various medicinal plants are becoming increasingly popular for the investigation of novel anticancer drugs. Traditional herbal medicinal plants have served as prime resources for the development of complementary medicine in anticancer therapy. Studies have demonstrated that Pomegranate may use as a natural remedy to chemical treatment due to its capability against a wide range of pathogens. There are wide ranges of phytochemical properties that have demonstrated anticancer activities in pomegranate. The present study aimed to evaluate the anticancer activity of leaves extract of Pomegranate on HT29 and MCF7 cancer cells by the MTT assay method. The maximum cell death of HT29 cells by the leaves extract of Pomegranate was 70.56±0.90% at 250 µg/mL concentration. The maximum cell death of MCF7 cells by the leaves extract of Pomegranate was 72.75±0.57% at 250 µg/mL concentration.