RNA interference studies in helminths of veterinary importance: A review

Abstract

With the advent of method of RNA interference (RNAi) in the era of prompt diagnosis and therapy of parasitic diseases caused by helminths has paved way to newer platforms. Various researchers have performed there studies on different trematodes like Fasciola hepatica, Fasciola gigantic and various nematodes viz; Ascarissuum, Haemonchus contortus, Ostertagia ostertagi, Trichostrongylus colubriformis etc. with considerable success. But still, the method needs to be validated further in absence of lack of consistency and reproducibility. Certain off-targets effects needs to be minimized. To combat drug resistance, the method of RNA interference stoods as an alternate approach to prevent parasitic diseases.