Biochemical studies on induced hyperlipidemia and its amelioration using aged garlic extract in Wistar rats

Abstract

The effect of aged garlic extract on different biochemical parameters was studied. The study included 72 Wistar albino rats, divided 12 in each group into six groups. Group I served as normal control group. To group II high fat diet was given as diet control. Rats in the group III were administered aged garlic extract at 200mg/kg bw. Group IV rats were administered aged garlic extract at 200mg/kg.bw with high fat diet. Rats in group V were administered atorvastatin at 15mg/kg.bw with high fat diet. The group VI rats with aged garlic extract and atorvastatin at half dose (100mg and 7.5mg/kg respectively) with high fat diet. The duration of the study was for 56 days and the blood samples were collected at 42nd and 56th day of study for evaluation. The high fat diet induced hyperlipidemia altered biochemical parameters; significant increase (P