Studies on the efficacy of stem cells for fracture healing in goats

Abstract

The study was conducted on twelve clinical cases of goats having long bone fracture randomly divided into two groups. In group I the fracture segment was immobilized by dynamic compression plate whereas, in group II after immobilization with dynamic compression plate mesenchymal stem cells were transplanted at fracture site. Exudates and pain at fracture site revealed a decreasing trend in both the groups from 7th to 15th post - operative day. A significant increase in weight bearing was observed from 7th post-operative day in both the groups of goat. Radiographic interpretation at different interval revealed early periosteal reaction, formation of soft and hard callus and initiation of remodeling in group II as compared to group I, The values of alkaline phosphatase increased non-significantly in all groups of goat up to 15th post-operative day, with maximum value at this interval. After reaching its maximum values, a decline in the values was observed in both the groups.