review Open AccessTop 1% cited
Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 107 randomized trials and 19,805 patients, on behalf of MACH-NC Group
Radiotherapy and Oncology · 2021 · Vol. 156 · pp. 281–293
Benjamin Lacas(Cleveland Clinic)Alexandra Carmel(Cleveland Clinic)C. Landais(Cleveland Clinic)Stuart J. Wong(Centre Hospitalier Universitaire Henri-Mondor)Lisa Licitra(Thomas Jefferson University Hospital)Jeffrey Tobias(Clinique de Genolier)Barbara Burtness(Oslo University Hospital)Maria Grazia Ghi(Centre Hospitalier Universitaire de Tours)Ezra E.W. Cohen(Medical College of Wisconsin)Cai Grau(Moffitt Cancer Center)Gregory T. Wolf(Centre Léon Bérard)Ricardo Hitt(Centre Antoine Lacassagne)Renzo Corvò(Tata Memorial Hospital)Volker Budach(State University of New York)Shaleen Kumar(Institut Curie)Sarbani Ghosh Laskar(European Organisation for Research and Treatment of Cancer)Jean‐Jacques Mazeron(Spanish Head & Neck Cancer Cooperative Group)Lai‐ping Zhong(Ospedale Policlinico San Martino)W. Dobrowsky(Institut Gustave Roussy)Pirus Ghadjar(Sidney Kimmel Cancer Center)C. Fallai(Centre Hospitalier Universitaire de Tours)Branko Zakotnik(Centre Léon Bérard)Atul Sharma(Cancer Research UK)René‐Jean BensadounMaria Grazia Ruo Redda(Rutgers, The State University of New Jersey)S. Racadot(University of Toronto)George Fountzilas(Swiss Group For Clinical Cancer Research)David M. Brizel(Centre Georges François Leclerc)P RoveaAthanassios Argiris(University of Chicago)Zoltán Takácsi Nagy(University Medical Center Groningen)Ju‐Whei Lee(Centre Jean Perrin)Catherine Fortpied(Centre Oscar Lambret)Jonathan Harris(Emory University)Jean Bourhis(Institut Sainte Catherine)Anne Aupérin(Cleveland Clinic)Pierre Blanchard✉(Cleveland Clinic)Jean‐Pierre Pignon(Cleveland Clinic)David J. Adelstein(Sidney Kimmel Cancer Center)M. Alfonsi(Institut Gustave Roussy)Y. Belkacemi(University Medical Center Groningen)Voichita Bar‐Ad(Ospedale San Giovanni Antica Sede)J. Bernier(Cleveland Clinic)Åse BratlandG. Calais(Inserm)Brittany Campbell✉(Inserm)Jimmy J. Caudell(Cleveland Clinic)Sylvie Chabaud(Institut Sainte Catherine)Emmanuel Chamorey(Inserm)Devendra Chaukar✉(Cleveland Clinic)Kwang Nam ChoiOlivier Choussy(Inserm)Laurence Collette✉(Inserm)Judith CruzCarla Dani✉(Inserm)Etienne Dauzier(Inserm)Arlene A. Forastiere(Duke Medical Center)P. Garaud(Inserm)V. Grégoire(Ospedale San Giovanni Antica Sede)A. HackshawE. Haddad(Inserm)Bruce G. HafftyAaron R. HansenStefanie Hayoz(Institut Sainte Catherine)Jean-Claude HoriotBranislav Jeremić✉(Inserm)Theodore KarrisonJohannes A. Langendijk(Sidney Kimmel Cancer Center)M. Lapeyre(Institut Gustave Roussy)Éric Lartigau(Inserm)Traci Leong(Université Paris-Sud)Quynh‐Thu Le(Centre Jean Perrin)Patricia Lee(Centre Jean Perrin)Freddi Lewin(Centre Oscar Lambret)Aihua LinAlberto LopesSamir Mehta(Institut Sainte Catherine)James Moon(Cleveland Clinic)Elizabeth Moyal(Inserm)Bob‐Valéry OccéanP. Olmi(Inserm)Roberto Orecchia(Inserm)Brian O’Sullivan✉(Inserm)Jens Overgaard(Cleveland Clinic)Claire Petit✉(Inserm)Harvey Quon✉(Inserm)Giuseppe Sanguineti(Inserm)Tuvana Satar(Université Paris-Sud)John Simes(Cleveland Clinic)Christian Simon✉(Inserm)Clément Sire✉(Inserm)S. Staar(Institut Sainte Catherine)C. Stromberger✉(Inserm)P. Strojan(Inserm)Stéphane Temam(Institut Sainte Catherine)David Thomson✉(Cleveland Clinic)A. TimochenkoValter Torri(Ospedale San Giovanni Antica Sede)Vassilikì Tseroni(Ospedale San Giovanni Antica Sede)Jan B. Vermorken(Cleveland Clinic)Everett E. Vokes(Centre Jean Perrin)John Waldron(Cleveland Clinic)Klaus‐Dieter WerneckeJoachim Widder(Cleveland Clinic)Björn Zackrisson✉(Inserm)
Abstract
The update of MACH-NC confirms the benefit and superiority of the addition of concomitant CT for non-metastatic head and neck cancer.
Head and Neck Cancer StudiesOral health in cancer treatmentCleft Lip and Palate ResearchMach numberMedicineHead and neckHead and neck cancerMeta-analysisOncologyInternal medicineCancerSurgeryMechanics
MeSH terms
Antineoplastic Combined Chemotherapy ProtocolsCarcinoma, Squamous CellHead and Neck NeoplasmsHumansRandomized Controlled Trials as TopicChemotherapy, AdjuvantInduction Chemotherapy
Funding
- American College of Radiology Imaging Network
- ECOG-ACRIN Cancer Research Group
- NRG Oncology
- Ligue Contre le Cancer
- Institut National Du Cancer
Citations
357
FWCI
46.68
field-weighted impact
References
140
Percentile
100%
vs. same field & year
Citations per year
References
A Proportional Hazards Model for the Subdistribution of a Competing Risk
Journal of the American Statistical Association · 1999 · 13,371 citations
Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 93 randomised trials and 17,346 patients
Radiotherapy and Oncology · 2009 · 3,022 citations
Quantifying heterogeneity in a meta‐analysis
Statistics in Medicine · 2002 · 36,106 citations
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