Experimental validation of vitamin C's defensive function against the biochemical changes triggered by a pyrethroid-based mosquito coil (PBMC) on testis of albino rats

Abstract

Allethrin is a widely used pyrethroid in mosquito coil and has a potential toxic effect. The purpose of the current research was to explore the effects triggered by allethrin-based mosquito coil smoke using an albino wistar rat model on certain biochemical parameters to ascertain the oxidative stress to be the mechanism of insult to testicular tissue. The animals in our study were clustered among the four groups. Group 1st, with 12 rats represented as control, while group 2nd having 12 rats, mosquito coil smoke was given to them 8 hours per day, seven days per week for twelve weeks. Group 3rd with 8 rats having the same exposure as in group 2nd and then kept for further 8 weeks without any exposure served as the withdrawal group. Group 4th, a maximum of ten rats with similar treatment as group 2nd, together with administration of vitamin C. Group 2nd rats showed derangement in oxidative markers compared to group 1st, 3rd, and 4th as there was a substantial amount of (P