The predictors of MDR organisms causing sepsis in neonates born in a tertiary care hospital

Abstract

There have been various studies in the direction of changing trends of antimicrobial sensitivity of organisms causing neonatal sepsis, though there have been no cumulative studies to demonstrate the risk factors, clinical profiles of neonates suffering from MDR and non MDR sepsis. Also there is no comparative data on the outcomes of MDR and non MDR neonatal sepsis. The present study aims to fill the aforementioned gaps. A prospective hospital based study over a period of one year was carried out at neonatal intensive care unit of our hospital, a tertiary care center. At least 20% deliveries require nursery admission. All neonates born at the hospital and presenting with signs and symptoms of sepsis or born to mothers with potential risk factors for sepsis were investigated for sepsis. The most common presenting symptom in both MDR and non MDR group was respiratory distress accounting for 54.84% of the total. Feed intolerance was seen in 3(9.68%) in the MDR group and 6(19.35%) in the non MDR group. Fever was seen in 3(9.68%) of MDR and 2(6.45%) of non MDR group. Lethargy was seen in 2(6.45%) of MDR and 1(3.23%) of non MDR group. There was no significant difference (p=0.092) in the symptomatology in the two groups.