A Study on Serum Immunoglooubin E levels as a marker in childhood asthma

Abstract

Background: Asthma is a chronic inflammatory of the lungs which causes bronchial hyperresponsiveness and reversible airway obstruction. The disease predominantly affects the children. Bronchial asthma is manifested in response to external trigger of allergens. The most important risk factor is atopy, which produces high amount of IgE, the aim of this study is to evaluate serum IgE levels as a marker for the disease activity and study the correlation with the severity of bronchial asthma. Methods: A prospective study was conducted in peadiatrics department of the tertiary care hospital from March 2019 to February 2019. Children between 6-12yrs admitted with clinical features of asthma as per GINA guidelines was included in the study. IgE levels were taken at the time of the initial presentation. Results: The study showed that all the participants 100% who presented with clinical features suggestive of asthma had high IgE levels irrespective of age, sex and severity of asthma. The mean IgE levels in females were more than males. As the severity of asthma increased the mean IgE levels also increased. Conclusion: The study conclude that the IgE levels are independent of age and sex. IgE levels are directly proportional to severity of asthma.