Inhibitory activities of ethanol extracts from Boesenbergia rotunda, Zingiber purpureum, and Alpinia galanga on in vitro agonists induced human platelet aggregation

Abstract

The rhizomes of Boesenbergia rotunda, Zingiber purpureum, and Alpinia galangal are well-known Thai medicinal plants has been used as spice and folk medicine due to its numerous functional and nutritional properties. The present study, the anti-platelet aggregation activities of the ethanol extracts from the rhizomes of rhizomes of B. rotunda, Z. purpureum, and A. galangal were evaluated using 96-well plate platelet aggregation assay. The ethanol extracts from B. rotunda, Z. purpureum, A. galanga (IC50 0.064 ± 0.039, 0.019±0.721, and 0.113±0.031 µg/mL) were more active than the ibuprofen (IC50 0.439 ± 0.064 µg/mL) in ADP-induced platelet aggregation (P