2-Chloroprocaine and Bupivacaine for lower abdomen and lower limb surgeries under spinal anesthesia: Effects on Haemodynamics

Abstract

Systemic absorption of local anesthetics produces effects on the cardiovascular and central nervous systems. At blood concentrations achieved with normal therapeutic doses, changes in cardiac conduction, excitability, refractoriness, contractility, and peripheral vascular resistance are minimal. However, toxic blood concentrations depress cardiac conduction and excitability, which may lead to atrioventricular block and ultimately to cardiac arrest. In addition, with toxic blood concentrations myocardial contractility may be depressed and peripheral vasodilation may occur, leading to decreased cardiac output and arterial blood pressure. Patients aged between 18 to 60 years of either gender, belonging to ASA Grade I and II, for elective lower limb and lower abdominal surgeries under spinal anaesthesia. In this present study, diastolic blood pressure recordings were not statistically significant between the two groups observed at different time intervals.