Efficacy of intravenous dexmedetomidine (0.5�g/kg) versus intravenous esmolol (1.5mg/kg) given before extubation on stress response to extubation

Abstract

Hypertension and tachycardia are well documented events during extubation3. These hemodynamic reflexes reflect sympatho-adrenal reflex stimulation (Epipharyngeal and laryngopharyngeal stimulation) with concomitant increase in plasma levels of catecholamines and activation of α and β adrenergic receptors. All patients included in the study were premedicated with tablet alprazolam 0.5 mg and tablet ranitidine 150 mg orally at bed time the previous night before surgery. They were kept nil orally 10 pm onwards on the previous night. Ten patients in the dexmedetomidine group and 4 patients in esmolol group had hypotension which was transient and responded to intravenous fluid administration was statistically significant compared to control group. The incidence of hypotension was statistically insignificant between esmolol and dexmedetomidine group.