Estimation of salivary biomarkers in patients with squamous cell carcinoma

Abstract

Introduction: Squamous cell carcinoma (SCC) is an epithelial malignancy that occurs in organs that are normally covered with squamous epithelium which includes several different anatomic sites. The present study was conducted to determine the role of salivary biomarkers in detection of SCC. Methods: The present study was conducted on 62 cases of oral squamous cell carcinoma of both genders. Subjects were divided into 2 groups. Group I had SCC patients whereas group II had control. Unstimulated whole saliva was collected and CYFRA 21‑1 and CA19‑9 were estimated by ELISA method while LDH level was assessed based on standard kit method. Results: Out of 62 patients, males were 42 and females were 20. The mean salivary biomarkers levels of LDH in group I was 424.8 and 112.5 in group II, CA19‑9 was 22.4 in group I and 20.5 in group II and CYFRA 21‑1 was 18.5 in group I and 3.6 in group II. The difference was significant (P