COVID-19-related acro-ischemia and topical calcium channel blockers: A useful therapeutic adjunct

Abstract

It is gradually now clear that one of the mainstays of COVID-19 infection lethality is represented by disseminated intravascular coagulation and venous thromboembolism, eventually leading to multiple pulmonary embolisms with subsequent profound hypoxia and respiratory failure in the adult patient. In this article we discuss if the severity of lesions in the critically affected adults is due to the combined effect of both a generalized coagulation disorder and a peripheral vasoconstriction, mainly due to the profound hemodynamic derangement and the effect of inotropic and vasoactive drugs used in the intensive care setting.