article Open AccessTop 1% cited
Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial
The Lancet Oncology · 2020 · Vol. 22(1) · pp. 29–42
Renu R. Bahadoer✉(Leiden University Medical Center)Esmée A. Dijkstra(University Medical Center Groningen)Boudewijn van Etten(University Medical Center Groningen)Corrie A.M. Marijnen(Leiden University Medical Center)Hein Putter(Leiden University Medical Center)Elma Meershoek‐Klein Kranenbarg(Leiden University Medical Center)Annet G.H. Roodvoets(Leiden University Medical Center)Irıs D. Nagtegaal(Radboud University Nijmegen)Regina G. H. Beets‐Tan(The Netherlands Cancer Institute)Lennart K. Blomqvist(Karolinska University Hospital)Tone Fokstuen(Karolinska University Hospital)Albert J. ten Tije(Amphia Ziekenhuis)Jaume Capdevila(Hebron University)Mathijs P. Hendriks(Northwest Hospital)Ibrahim Edhemović(Institute of Oncology Ljubljana)Andrés Cervantes(Universitat de València)Per J. Nilsson(Karolinska University Hospital)Bengt Glimelius(Uppsala University)Cornelis J.�H. van de Velde(Leiden University Medical Center)Geke A.P. Hospers(University Medical Center Groningen)Lars ØstergaardFrank Svendsen JensenPer PfeifferK.E.J. JensenMathijs P. Hendriks(Northwest Hospital)Wilhelmina H. SchreursH.P. KnolHans van VlietJurriaan B. TuynmanA. BruynzeelEmile D. KerverSebastiaan FestenMonique E. van LeerdamGeerard L. BeetsL. DewitC.J.A. PuntPieter J. TanisElisabeth D. GeijsenPeter NieboerWim BleekerAlbert J. ten Tije(Amphia Ziekenhuis)Rogier M. P. H. CrollaAddy C.M. van de LuijtgaardenJan Willem T. DekkerJ.M. ImminkFrank J. JeurissenAndreas MarinelliHeleen M. CehaTanja C. StamP. Quarles an UffordWillem H. SteupAlex L.T. ImholzR.J.I. BoskerJasper BekkerG.J. CreemersGrard A. P. NieuwenhuijzenHenk van den BergWendy M. van der DeureRoderick F. SchmitzJohan M. van RooijenAnnette F. T. OliemanA.C.M. van den BerghDerk Jan A. de GrootKlaas HavengaJannet C. BeukemaJacob D. de BoerPeter H.J.M. VeldmanEster SiemerinkJ.W.P. VanstiphoutB. De ValkQ. A. J. EijsboutsM. PoléeChristiaan HoffAnnerie SlotH.W. KapiteijnKoen PeetersFemke P. PetersP.A. NijenhuisSandra A. RademaHans De WiltPètra M. BraamG.J. VeldhuisDaniël A. HessTom RozemaO. ReerinkDaan ten Bokkel HuininkA. PronkJosephine M. I. VosMetin TascilarGijs A. PatijnChristian KerstenOdd MjålandMarianne G. GurenArild NesbakkenJanez BenedikIbrahim Edhemović(Institute of Oncology Ljubljana)Vaneja VelenikJaume Capdevila(Hebron University)Eloy EspínRamón SalazarSebastiano BiondoVanessa PachónJavier Díe TrillJorge AparicioE. Garcia GraneroMaría José SafontJuan Carlos Guerrero BernalAndrés Cervantes(Universitat de València)Alejandro Espí MacíasLena MalmbergG SvaningerHelene HörbergG. DafnisÅke BerglundLars ÖsterlundKatalin Réka KovácsJeroen HolS. OttossonGöran CarlssonCharlotte BratthällJohanna C. Andersson‐AssarssonBritta LödénPer HedeIngrida VerbienéOlof HallböökAnna JohnssonM L LydrupK. VillmannPeter MatthiessenJohan SvenssonJohan HauxS. SkullmanTone Fokstuen(Karolinska University Hospital)T. HolmPetra FlygareMaria WalldénBirgitta LindhOwe LundbergCalin RaduLars PåhlmanAndrzej PiwowarKenneth SmedhU. PaleniusStaffan JangmalmP. ParinkhH. KimMatthew L. Silviera
Colorectal Cancer Surgical TreatmentsColorectal and Anal CarcinomasColorectal Cancer Screening and DetectionMedicineTotal mesorectal excisionRadiation therapyColorectal cancerChemoradiotherapySurgeryStage (stratigraphy)Clinical endpointChemotherapyRandomized controlled trial
MeSH terms
AdenocarcinomaAgedAntineoplastic Combined Chemotherapy ProtocolsEuropeFemaleHumansMaleMiddle AgedNeoplasm Recurrence, LocalNeoplasm StagingRectal NeoplasmsDigestive System Surgical ProceduresTime FactorsUnited StatesTreatment Failure
Funding
- Cancerfonden
- Ministerio de Economía y Competitividad
- Vetenskapsrådet
- KWF Kankerbestrijding
- Spanish Clinical Research Network
- Instituto de Salud Carlos III
- European Regional Development Fund
Citations
1,545
FWCI
64.18
field-weighted impact
References
39
Percentile
100%
vs. same field & year
Citations per year
References
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Long-term results of a randomized trial comparing preoperative short-course radiotherapy with preoperative conventionally fractionated chemoradiation for rectal cancer
British journal of surgery · 2006 · 1,238 citations
Classification of Surgical Complications
Annals of Surgery · 2004 · 30,306 citations
Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: a pooled analysis of individual patient data
The Lancet Oncology · 2010 · 1,927 citations
Short-course radiotherapy followed by neo-adjuvant chemotherapy in locally advanced rectal cancer – the RAPIDO trial
BMC Cancer · 2013 · 295 citations
The TME Trial After a Median Follow-up of 6 Years
Annals of Surgery · 2007 · 1,187 citations
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