To evaluate and standardize the method of spot urine protein creatinine ratio for estimation of proteinuria

Abstract

Background: Proteinuria is an independent risk factor for diabetic nephropathy and a predictor of end-stage renal disease. Measurement of protein excretion in a 24hr urine collection is the gold standard for the quantitative evaluation of proteinuria in diabetes. However, this is cumbersome, subjective to collection errors and required good compliance. Aims: To evaluate and standardize the method of spot urine protein creatinine ratio for estimation of Proteinuria. Materials and methods: We compared 24 hr urine protein estimation with urine spot protein creatinine ratio in type 2 diabetes mellitus patients with proteinuria. Results: In our study of 73 patients with type 2 diabetes mellitus and proteinuria, it was found that A maximum number of patients were noted in the age group 41-50 years. Males were more than females in the ratio of 2.04:1. The majority of patients had a duration of diabetes between 5 -10 yrs (52.05%). The mean duration of diabetes was 9.24+/- 6.1 yrs. Twenty-five patients (34.25%) had nephrotic range proteinuria. There was a good correlation between urine PCR and 24 hr urine protein at different levels of GFR. Maximum correlation between urine PCR and 24 hr urine protein was seen in the GFR >60 group. There was a good correlation between urine PCR and 24 hr urine protein at different ranges of proteinuria. A maximum correlation between urine PCR and 24 hr urine was seen in the proteinuria group