Safety assessment of the water extract of Munronia pinnata in wistar rats

Abstract

Munronia pinnata (Meliaceae) is an important medicinal plant in Sri Lanka and it hasbeen broadly used for skin diseases, diabetes, fever and dysentery in the form of concoction and powder due to its bitterness. In Sri Lanka thishas been applied for hundreds of years asunorthodox medicine. This study was focused to assess the possible toxicity of the water extracts of M. pinnata (MPW) in healthy and diabetic Wistar rats. Acute and chronic administration of MPW produced no neither mortality nor changes in general behaviors compared with Control groups. The results showed no statistically significant changes in hematological and biochemical values of Test groups compared to the control groups of both healthy and diabetic animals. These results disclosed that the water extract of M. pinnata do not cause any undesirable effects as evaluated by the attempted studied.