Study of prothrombin time and activated partial thromboplastin time in type ii diabetes mellitus

Abstract

Introduction:Diabetes is a major health problem and it is characterized by a high risk of atherothrombotic events. In patient with diabetes mellitus, persistent hyperglycaemia exposes red blood cells (RBCs) to elevated glucose concentration, thus resulting in glycation of haemoglobin, prothrombin, fibrinogen and other proteins involved in clotting mechanisms. Aim & Objectives: To determine hypercoagulability state of Type 2 Diabetes Mellitus patients by measuring the haemostatic profiles. Material & Method: The study was an analytical study involving diabetic patients attending S.S.G. Hospital Diabetic clinic. A total of 160 subjects aged 19-71 years participated in the study out of which 80 participants were T2DM patients and 80 were control subjects. Results & Conclusion: T2DM patients had shortened PT, APTT than the healthy non-diabetic controls. This indicates higher risk of thrombosis in T2DM patients. This study reveals that diabetic patients who had poor glycaemic control were at risk of hypercoagulability than those with good glycaemic control.