Comparative study between PRP and hyluronidase injection on fibrous site for OSMF

Abstract

Background: OSMF is one of the disorders affecting oral cavity, and sometimes pharynx. It is kind of potential malignant disorder associated with betel nut chewing and some nutritional deficiencies. Medical treatment of OSMF has been not completely systematized and no perfect and broadly accepted treatment is presently accessible for this condition. Objective: To evaluate the efficacy of PRP and hyluronidase injections for the management of OSMF. Materials and Methods: Present study was carried out in 30 patients with OSMF of different clinical grade (Grade III, IV, V). The patients were administered with 0.5 ml of Hyaluronidase 1,500 IU was mixed in 1 ml of lignocaine as well as 0.5 ml of PRP (Platelets rich plasma) injected intralesionally in fibrosis of OSMF, once a week. Results: Results of ANOVA suggested that after treatment with these two injections there were significant improvement or relief in symptoms were observed. Thus treatments significantly work to relief the symptoms. There was significant difference found between pre and post treatment (p value<0.05). Conclusion: Treatment with hyaluronidase and PRP is an efficient mean of managing OSMF and can decrease the symptoms and provide relief to the certain extent.