Assessment of anti-candidial activity of different homoeopathic medicines against Candida albicans

Abstract

Background: Now a days, there is an increase in the number of patients affected by recurring candidiasis due to the development of antifungal resistance in pathogenic candida species. Therefore, the present study was conducted to assess the anti-candidial activity of different homeopathic medicines against Candida albicans. Material and methods: The present study was conducted among 60 patients. Before commencement of study permission was taken from the ethical committee of the institute. Homoeopathic mother tincture (ф) of S. jambolanum, F. religiosa, O. sanctum, A. cepa, were prepared. Commercially available antifungal drugs Ketoconazole (10 μg/ml) was used as positive control and 90% alcohol was used as vehicle control. The fungal culture of C. albicans procured as lyophilised freeze-dried culture strain was used to evaluate antifungal activity of homoeopathic drugs. The statistical data were analysed using one-way analysis of variance (ANOVA). P < 0.05 was considered as significant as compared to vehicle control. Results: The results of this study shows that S. Jambolanum had maximum mean zone of inhibition. S. Jambolanum had maximum percentage zone of inhibition. Conclusion: The results of our study concluded that S. Jambolanum was even better than Ketoconozole.