Evaluation of acid neutralizing and antiulcer potential of a poly-herbal formulation

Abstract

The present study was planned to evaluate the acid neutralizing and antiulcer potential of a polyherbal formulation by using various models like neutralization of 0.1N hydrochloric acid, acid neutralization capacity using artificial stomach model, asprin plus pylorus ligation induced gastric ulcer model, protein precipitation assay and prokinetic effect using isolated rat ileum. The toxicity studies were conducted and it was safe at a dose of 5000mg/kg. The in-vitro study revealed its significance statistically in acid neutralizing when compared to control group. The formulation also showed potential results with aspirin ligation method when compared to control with respect to ulcerative index, total acidity, total acid output at a dose of 200mg/kg. Thus, it can be said that the polyherbal formulation is considered to be safe and effective in treating patients with high acidity as compared to marketed formulation.