Synthesis of Quinoline-Thiazole Compound (Ethyle 2-Chloroquinoline-3-yl) Methylene amino)-4-methylthiazole-5-carboxylate)

Abstract

Compounds classified as heterocyclic probably constitute the largest and most varied family of organic compounds, every Carbo-cyclic compound, regardless of structure and functionality may in principle be converted into a collection of heterocyclic analogs by replacing one or more of the ring carbon atoms with a different element. Quinoline is a heterocyclic aromatic organic compound with the chemical formula C9H7N. It is a colorless hygroscopic liquid with a strong odor. Aged samples, especially if exposed to light, become yellow and later brown. Quinoline is only slightly soluble in cold water but dissolves readily in hot water and most organic solvents. Quinoline-Thiazole compound have been prepared by the reactions of different chemical compounds. First aniline reacts with acetyl chloride to give acetanilide. Acetanilide undergoes Vilsmeier reaction by involving use of DMF and POCl3 to give aldehyde. Ethyl acetoacetate on the other hand reacts with THF and Thiourea to yield Thiazole. Aldehyde then reacts with the Thiazole in presence of glacial acetic acid to give the desired compound.