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Maternal Immunological Adaptation During Normal Pregnancy

Frontiers in Immunology · 2020 · Vol. 11 · pp. 575197–575197

Bahaa Abu-Raya✉(University of British Columbia)Christina Michalski(BC Children's Hospital)Manish Sadarangani(BC Children's Hospital)Pascal M. Lavoie(BC Children's Hospital)

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Abstract

The risk and severity of specific infections are increased during pregnancy due to a combination of physiological and immunological changes. Characterizing the maternal immune system during pregnancy is important to understand how the maternal immune system maintains tolerance towards the allogeneic fetus. This may also inform strategies to prevent maternal fatalities due to infections and optimize maternal vaccination to best protect the mother-fetus dyad and the infant after birth. In this review, we describe what is known about the immunological changes that occur during a normal pregnancy.

Reproductive System and Pregnancy COVID-19 Impact on Reproduction Pregnancy and Medication ImpactPregnancyFetusImmune systemVaccinationAdaptation (eye)MedicineImmunologyBiologyNeuroscience

MeSH terms

AnimalsFemaleHumansImmune SystemImmunity, CellularImmunity, InnateMaternal-Fetal ExchangePregnancyPregnancy ComplicationsHistocompatibility, Maternal-FetalAdaptive ImmunityImmunity, Humoral

Citations

603

FWCI

23.07

field-weighted impact

References

290

Percentile

100%

vs. same field & year

Citations per year

References