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Tralokinumab for moderate‐to‐severe atopic dermatitis: results from two 52‐week, randomized, double‐blind, multicentre, placebo‐controlled phase III trials (ECZTRA 1 and ECZTRA 2)*
British Journal of Dermatology · 2020 · Vol. 184(3) · pp. 437–449
Andreas Wollenberg✉(Ludwig-Maximilians-Universität München)Andrew Blauvelt(Oregon Medical Research Center)Emma Guttman‐Yassky(Icahn School of Medicine at Mount Sinai)Margitta Worm(Charité - Universitätsmedizin Berlin)Charles Lynde(University of Toronto)J.‐P. Lacour(Centre Hospitalier Universitaire de Nice)Lynda Spelman(Veracity Clinical Research)Norito Katoh(Kyoto Prefectural University of Medicine)Hidehisa Saeki(Nippon Medical School)Yves Poulin(Centre de Recherche Dermatologique du Québec Métropolitain)Aleksandra Lesiak(Medical University of Lodz)Leon Kircik(University Medical Center)S.H. Cho(Catholic University of Korea)Pedro Herranz(Hospital Universitario La Paz)Michael J. Cork(University of Sheffield)Ketty Peris(Agostino Gemelli University Polyclinic)Louise Abildgaard Steffensen(Leo Pharma (Denmark))B K Bang(Leo Pharma (Denmark))Alexandra Kuznetsova(Leo Pharma (Denmark))T.N. Jensen(Leo Pharma (Denmark))Marie Louise Østerdal(Leo Pharma (Denmark))Eric L. Simpson(Oregon Health & Science University)the ECZTRA 1 and ECZTRA 2 study investigators
Abstract
Tralokinumab monotherapy was superior to placebo at 16 weeks of treatment and was well tolerated up to 52 weeks of treatment.
Dermatology and Skin DiseasesAllergic Rhinitis and SensitizationAsthma and respiratory diseasesPlaceboAtopic dermatitisDouble blindMedicineRandomized controlled trialPhysical therapyDermatologyInternal medicineAlternative medicine
MeSH terms
AdultAntibodies, MonoclonalDermatitis, AtopicDouble-Blind MethodEczemaHumansSeverity of Illness IndexTreatment Outcome
Funding
- LEO Pharma
Citations
563
FWCI
42.91
field-weighted impact
References
24
Percentile
100%
vs. same field & year
Citations per year
References
Epidemiology of atopic dermatitis in adults: Results from an international survey
Allergy · 2018 · 860 citations
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