Haemato-biochemical changes before and after therapy with ivermectin and levamisole in Gastrointestinal Nematodes infected goats

Abstract

368 goats were presented to the Campus Veterinary Hospital and Ambulatory Clinical Services, Mylardevpally, College of Veterinary Science, Hyderabad, from December-2017 to June-2018. Out of which 140 goats (38.04%) were found positive for gastrointestinal nematodal infestation. 10 apparently healthy goats, which were negative for gastrointestinal nematodal infestation were selected, subjected to haematological and biochemical investigations and they served as healthy control (group I). Goats positive for gastrointestinal nematodal infestation were randomly divided into two groups (II and III) with each group having 10 positive cases and studied haematological and biochemical changes on day 0 of before therapy and day 7 of after therapy in ivermectin and levamisole treated groups of II and III respectively, There was significant (P<0.05) changes noticed in the mean Haemoglobin (9.73 ± 0.01 and 9.67 ± 0.01), Packed cell volume (26.59 ± 0.58 and 26.21 ± 0.33), Total erythrocyte counts (11.34 ± 0.01 and 11.23 ± 0.007), lymphocytes (49.14 ± 0.95 and 49.42 ± 0.34), Total serum proteins (5.14 ± 0.03 and 5.31 ± 0.03), Albumin levels (1.92 ± 0.04 and 2.02 ± 0.04) whereas, significant (P<0.05) increase in Total leucocyte counts (10.68±0.01 and 10.98 ± 0.02), eosinophils (7.12 ± 0.17 and 6.97 ± 0.10), monocytes (3.01 ± 0.03 and 2.96 ± 0.01), Globulin (3.22 ± 0.03 and 3.29 ± 0.05) and Alanine aminotransferase levels (26.09 ± 0.33 and 24.19 ± 0.52) on before therapy in group II and III respectively, and found normal levels after therapy.