Polymorphism of insulin-like growth factor-i gene and their association with weight at different age in Assam hill goats

Abstract

The present investigation was carried out to study the occurrence of polymorphism in Insulin-Like Growth Factor- I (IGF-I) gene in Assam Hill Goat, a meat type variety of Assam, India and to study the association of polymorphic genes with body weight at different ages. A total of 256 blood samples, collected from male goats of different field units and Goat Research Station, Assam Agricultural University (AAU), Burnihat under the ICAR sponsored project entitled “ICAR-All India Coordinated Research Project on Goat Improvement” were utilized for the present study. Three genotypes, viz. AA (28.91%), AB (27.34%) and BB (43.75%) were detected with frequencies of 0.19, 0.49 and 0.33 respectively. The allele frequency for A and B were observed to be 0.43 and 0.57. Chi-square test revealed that the population was not in Hardy-Weinberg Equilibrium for the gene. The mean body weights (kg) along with SE of the AA, AB and BB genotypes detected in IGF-I gene were observed to be 1.16 ± 0.03, 1.21 ± 0.03 and 1.14 ± 0.02; 5.03 ± 0.11, 4.79 ± 0.09 and 4.95 ± 0.08; 6.90 ± 0.13, 7.17 ± 0.13 and 7.50 ± 0.09; 9.93 ± 0.17, 9.88 ± 0.17 and 9.99 ± 0.13 and 13.42 ± 0.18, 12.97 ± 0.18 and 13.16 ± 0.15, respectively. However, statistically there was no significant (p>0.05) difference in body weights among the different genotypes.