A study on demonstration of collagen and acid mucopolysacharides in diffuse myxomatous valvular degeneration in dogs

Abstract

A nine years old, male non-descript dog was presented with the history of anorexia, lethargy, exercise intolerance, coughing and recumbency for two weeks. Auscultation revealed heart murmur. Necropsy showed tricuspid valve was very thick and opaque. Histopathologically there was deposition of myofibroblst. Alcian blue staining revealed diffuse infiltration of mucopolysacharides and extensive decrease in amount of collagen in tricuspid valve in comparison to mitral valve in masson’s trichrome staining. Based on physical and clinical observations, postmortem and pathological examinations were confirmed the disease condition as diffuse myxomatous tricuspid valvular degeneration.