Gross and histopathological changes in canine chronic kidney disease

Abstract

Chronic Kidney Disease brings structural and functional changes in one or both the kidneys. The structural changes include changes in glomeruli, renal tubules, interstitial space, renal pelvis and vascular tissue. Total of 9 renal tissue samples were collected from dogs which die due to CKD and submitted to laboratory for histopathological examination. Histopathology examination of collected samples was performed with light microscopy using hematoxylin and eosin stain. On gross examination kidney size was reduced, shape was irregular and capsule was peeled off with difficulty. On histopathological examination changes like lymphoplasmacytic infiltration, tubular atrophy, dystrophic calcification and interstitial fibrosis were indicative of chronic nephritis.