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Role of Cressa cretica on CCl4- induced liver damage in experimental rats
Journal of Pharmacognosy and Phytochemistry · 2018 · Vol. 7(1) · pp. 1368–1373
Abstract
The present study was undertaken to evaluate the role of Cressa cretica aerial part's extract on tissue-lipid peroxidation, antioxidant status and serum markers in experimental rat liver damage. The liver was damaged in experimental rats with the administration of 1:1 (v/v) mixture of CCl4 (carbon tetrachloride) in olive oil at the dose level of 1 ml/kg body weight on once a week, intra-peritoneally (ip). The methanol extract of Cressa cretica (50mg/kg and 100mg/kg) and standard drug- silymarin (25mg/kg) were given orally to rats from day 1 to 21. The extract of C. cretica produced significant (P
Drug-Induced Hepatotoxicity and ProtectionSphingolipid Metabolism and SignalingLiver Disease Diagnosis and TreatmentCarbon tetrachlorideCCL4AntioxidantLiver damageLipid peroxidationPharmacologyTraditional medicineBody weightChemistryOlive oil
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