Development and evaluation of anti-urolithiatic herbal formulation

Abstract

According to the WHO herbal medicine are the medicinal products that contain an active herbal ingredient in aerial or underground parts of a plant. The use of herbal formulations now-a-days is increasing rapidly and due to this it was thought to make an anti-Urolithiatic herbal formulation with a reduced dosage and enhanced onset of action. Out of three herbal plants namely; Lycopodium clavatum, Berberis Vulgaris and Smilax Officinalis used for Urolithiasis, it was found by in-vitro screening that Lycopodium clavatum had excellent activity. To assess the pharmacokinetics various tests were performed namely, in-vitro dissolution study of calcium oxalate crystals, %inhibition of calcium oxalate crystals, whereas the cytotoxicity was tested by MTT Assay.