Effect of methanol extract of Bryophyllum pinnatum leaves on ethylene glycol-induced urolithiasis in adult male albino rats

Abstract

Methanol extract of Bryophyllum pinnatum was used to evaluate its antilithic property in adult male albino rats. Experimental urolithiasis was induced by oral administration of ethylene glycol and ammonium chloride with drinking water for 7 days. The treatment with methanol extract of Bryophyllum pinnatum and cystone by oral administration was continued for 14 days. Fresh urine samples were collected daily for urine crystal counts. On 14th day fresh urine and serum samples were collected for creatinine estimation and rats were sacrificed for kidney histopathology. An increased serum creatinine and decreased urine creatinine level were observed in urolith group, where as the findings did not differ significantly in Bryophyllum pinnatum extract and cystone treated groups with the control group. Urine crystal counts were significantly reduced and histopathology of kidney showed apparently normal architecture with very less crystal deposition in kidneys of the Bryophyllum pinnatum extract and cystone treated groups.